James Cameron isn’t worried about his Avatar sequels taking back the throne from Avengers: Endgame. But he’s not ignoring the idea, either. He’s a blockbuster guy. He’s not going sniff at something popular in the zeitgeist — although he did say he hoped we’ll soon “start getting Avenger fatigue.” He’s usually the guy making the popular thing in the zeitgeist. He’s actively “trying” to do it again with the Avatar sequels, and if anyone can get lightning to strike a third time, it’s the director who had back-to-back highest-grossing movies ever with Titanic and Avatar.
James Cameron has been busy since Avatar came out in 2009 and did pretty prettay good at the box office, becoming the highest-grossing movie of all time and keeping that title for 10 years. However, Cameron hasn’t directed any feature films since then. Avatar 2, which comes out in 2021, will be the next film that he directs.